MRP2 — Neurospora crassa

Summary

NCU00564 (MRP2) on Neurospora crassa chromosome 1 encodes a structural constituent of the ribosome, belonging to the Ribosomal_uS14 family, and is a component of the mitochondrial ribosomal small subunit complex. The gene is associated with translation, particularly mitochondrial translation, and localises to the mitochondria and mitochondrial inner membrane. MRP2 is associated with numerous phenotypes including abnormal or absent vegetative growth, decreased respiratory growth, increased mitophagy, increased mutation frequency, decreased replicative and chronological lifespan, and altered stress resistances such as decreased UV, acid pH, desiccation, and thermotolerance, alongside increased oxidative stress and metal resistance in some contexts. It is also associated with abnormal lipid particle morphology, decreased nucleolus size, and impaired nitrogen source utilisation. Related genes in other species are linked to increased mitochondrial rho- mutation frequency and altered carbon source utilisation.