HHP1 — Neurospora crassa

Summary

NCU00685, also known as HHP1, ck-1a, or HRR25 on Neurospora crassa chromosome 1, encodes a casein kinase I family member with protein serine/threonine kinase activity, protein tyrosine kinase activity, and ATP and magnesium binding. This gene is associated with the regulation of vesicle fusion with the Golgi apparatus, ER-to-Golgi vesicle-mediated transport, and positive regulation of clathrin-mediated endocytosis. It is linked to meiotic processes including homologous chromosome segregation, spindle attachment to the meiosis I kinetochore, and positive regulation of double-strand break repair. HHP1 is also associated with SREBP signalling, negative regulation of ergosterol biosynthesis, and positive regulation of filamentous growth. Phenotypic associations include delayed vegetative growth, abnormal spore germination, increased sporulation rate, decreased cell cycle progression, and absent peroxisomal transport. The protein localises to the spindle pole body, growing cell tip, and vacuolar lumen.