tcu-1 — Neurospora crassa

Summary

NCU00830 (tcu-1) on Neurospora crassa chromosome 1 encodes a Cop_transporter family protein with copper ion transmembrane transporter activity. The gene is associated with copper ion import into the cell, copper ion membrane transport, innate immunity, excretion, secretion, and regulation of gene expression. Its product localises to the fungal-type vacuole, plasmalemma, and membrane. Studies of related genes in other species link the family to reduced virulence and cryptococcal meningitis, though these associations are not established for N. crassa.