GIT7 — Neurospora crassa

Summary

NCU01118 (GIT7, NcGIT7) on Neurospora crassa chromosome 5 encodes an SGS-domain-containing protein with chaperone protein binding activity, belonging to the Sgt1-like family that includes HSP20-like chaperone and TPR-like helical domains. The gene is associated with virus-induced PTGS, the glucose-sensing PKA pathway, protein folding, and cell death, and localises to the cytoplasm, cytosol, and nucleus. Phenotypic associations include increased nuclear import, altered cell cycle progression (G1/S arrest, G2/M delay), abnormal meiotic recombination and chromosome segregation, increased starvation resistance and acid pH resistance, decreased mating response and gamma ray resistance, and absent pexophagy and autophagy.