TOM40 — Neurospora crassa

Summary

NCU01179, TOM40 on Neurospora crassa chromosome 5, encodes a porin with protein translocase and ATP hydrolase activities, belonging to the Tom40_fungi and Porin_Euk/Tom40 domain families. It is a component of the mitochondrial outer membrane translocase (TOM) complex and localises to mitochondria and the TOM complex pore. The gene is associated with mitochondrial protein import across the outer membrane, matrix and inner membrane, TOM complex assembly, monoatomic ion transport, mitochondrion distribution, proteolysis, and protein transport. Phenotypic associations include decreased oxidative phosphorylation, abnormal or absent respiratory metabolism, absent spore germination and filamentous growth, decreased fermentative growth and ribophagy, arrested cell cycle progression in metaphase, absent mitophagy and endocytosis, increased mitochondrial genome maintenance and rho- mutation frequency, and altered protein/peptide distribution and RNA modification. Related genes in other species link the family to mitochondrial import receptor function.