ATF1 — Neurospora crassa

Summary

NCU01345 (ATF1, asl-1) on Neurospora crassa chromosome 5 encodes a bZIP transcription factor with DNA-binding, nucleosome-binding, and recombination hotspot-binding activities. It is associated with activation of reciprocal meiotic recombination, suppression of meiotic recombination, circadian rhythm, stress-activated MAPK cascade, HOG response, cellular response to copper, asexual reproduction, sexual reproduction, secondary metabolism, negative regulation of antisense RNA transcription, and negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling. The protein localises to the nucleus, chromatin, and heterochromatin, and is linked to the Atf1-Pcr1 complex. Related genes in other species connect the family to calcium sensitivity, acid sensitivity, oxidative stress response, and reduced virulence.