TUP1 — Neurospora crassa

Summary

NCU01389, designated TUP1 on Neurospora crassa chromosome 5, encodes a mitogen-activated protein kinase organizer 1 (MORG1) containing WD40 repeat domains. The product exhibits transcription corepressor activity, mediator complex binding, histone deacetylase binding, histone binding, kinase activity, GTP binding, and phosphatidylinositol-3,5-bisphosphate binding. TUP1 is associated with carbon catabolite repression, the HOG response, regulation of glycogen metabolism, regulation of fatty acid anabolism, negative regulation of dipeptide transport, flocculation, conidia formation, spore formation, mitotic cell cycle, mRNA splicing via the spliceosome, DNA damage response, chromatin modeling, and negative regulation of transcription by RNA polymerase II. The protein localizes to transcription repressor complexes, the Tup11/Tup12 repressor complex, spliceosomal complexes, chromatin, and histone methyltransferase complexes. Studies of related genes in other species link the family to additional uncharacterized WD repeat-containing proteins.