ATRR — Neurospora crassa

Summary

NCU01478 (ATRR, NcATRR) on Neurospora crassa chromosome 5 encodes a fungal-specific transcription factor domain-containing protein with a Zn2Cys6 DNA-binding domain and an AtrR-like domain. The product has sequence-specific DNA binding and RNA polymerase II transcription factor activity, and is associated with sterol and ergosterol anabolism, sterol homeostasis, and positive regulation of transcription. It localises to the nucleus, membrane and cytosol. Studies of related genes in other fungi link the AtrR family to reduced virulence and pulmonary aspergillosis.