GPD3 — Neurospora crassa

Summary

NCU01528 (GPD3, gpd-1) in Neurospora crassa encodes a glyceraldehyde-3-phosphate dehydrogenase (GAPDH) with NAD⁺ and NADP⁺ binding activity, catalysing the phosphorylating step of glycolysis (EC 1.2.1.12). The enzyme localises to the cytosol and is associated with glycolytic and glucose metabolism processes. The gene is also linked to mating type switching, meiosis, mating, cell death, and autophagy. Phenotypic associations include altered colony colour, plasma membrane morphology, and adhesion; loss of anaerobic growth and desiccation resistance; increased resistance to gamma, X-ray, and UV radiation; increased polyploidy and meiotic recombination; delayed mitotic cell cycle; decreased pexophagy, fermentative growth, and chemical compound excretion; and altered pheromone-induced cell cycle arrest and nuclear import. Studies of related genes in other species connect the family to potassium concentration traits.