CYC1 — Neurospora crassa

Summary

NCU01808, designated cyc-1 (CYC1) in Neurospora crassa on chromosome 2, encodes a cytochrome c family protein with electron transfer activity and heme binding. The gene is associated with mitochondrial electron transport chains, including ATP synthesis coupled electron transport, ubiquinol to cytochrome c transfer, and cytochrome c to oxygen transfer. It localizes to mitochondria, the mitochondrial envelope lumen, and the respirasome. CYC1 is associated with filamentous growth, cell-cell adhesion, and the glucose effect. Phenotypic associations include decreased respiratory metabolism, abnormal cell cycle progression, altered mitochondrial transport, reduced pseudohyphal growth, and increased mitochondrial genome maintenance. The gene is also associated with oxidative stress resistance, autophagy, vacuolar transport, chromosome segregation, and petite-negative growth patterns. Related genes in other species link the family to oxidative stress response.