REV3 — Neurospora crassa

Summary

NCU01951, also known as REV3 or upr-1 in Neurospora crassa on chromosome 1, encodes a DNA-directed DNA polymerase with 3'-5' exonuclease activity, DNA replication origin binding, and 4Fe-4S cluster binding. It is a member of the DNA polymerase B family and the zeta polymerase complex. The gene is associated with DNA repair processes including base-excision repair gap-filling, nucleotide-excision repair DNA gap filling, and response to UV and UV-A. It is linked to nuclear and mitochondrial DNA replication, lagging and leading strand elongation, and proofreading. Phenotype associations include abnormal sporulation efficiency, mating response, and meiotic recombination, as well as decreased resistance to chemicals, increased mitochondrial genome maintenance, increased necrotic cell death, and decreased lifespan. The gene product localizes to the nucleus, mitochondria, chromatin, replication forks, and telomeric regions.