cfp — Neurospora crassa

Summary

NCU02193 (cfp) on Neurospora crassa chromosome 7 encodes a pyruvate decarboxylase (EC 4.1.1.1), a thiamine pyrophosphate-dependent enzyme. The product contains TPP-binding and DHS-like NAD/FAD-binding domains and exhibits pyruvate decarboxylase activity, TPP binding, magnesium binding and identical protein binding. The gene is associated with pyruvate metabolism, ethanol fermentation, zinc transport, secretion, chromosome division, methylation and DNA repair. It localises to the cytosol, nucleus, cell-bound fraction and fungal biofilm matrix. Related genes in other species link the family to Fusarium oxysporum, though this is not established for N. crassa.