PRR1 — Neurospora crassa

Summary

NCU02413 (PRR1, rrg-2) on Neurospora crassa chromosome 7 encodes a phosphorelay response regulator with DNA-binding transcription activator activity, RNA polymerase II-specific, and transferase activity. The protein contains a Sig_transdc_resp-reg_Skn7 domain, an HSF DNA-binding domain, and a CheY-like receiver domain, and localises to the nucleus, cytoplasm, chromatin, and RNA polymerase II transcription regulator complex. PRR1 is associated with response to singlet oxygen, cellular thermotolerance, osmotic response, ER stress response, MAPK cascade, conidiophore development, germ tube formation, cell size control, and nuclear division. It is linked to oxidative stress resistance, thermotolerance, cell cycle progression through G1/S phase transition, filamentous growth, flocculation, biofilm formation, spore germination, mating efficiency, and carbon source utilisation. Related genes in other species connect it to response to pH and phosphate content.