HGT12 — Neurospora crassa

Summary

NCU02582 (HGT12, sor-4) on Neurospora crassa chromosome 1 encodes a hexose transmembrane transporter belonging to the major facilitator superfamily (MFS) of sugar transporters. The gene product exhibits high-affinity glucose:proton symporter activity, D-glucose binding, and galactose transmembrane transporter activity. It is associated with carbon catabolite repression, hexose and galactose import across the plasma membrane, glucose-mediated signalling, and the meiotic cell cycle. The protein localises to the plasma membrane at the cell tip, the cell division site, the fungal-type vacuole and its lumen, the mitochondrial membrane, and the cytoplasm. Related genes in other species, including Verticillium dahliae and Fusarium oxysporum, are linked by sequence similarity.