RICA — Neurospora crassa

Summary

NCU02788 (RICA, ric8) on Neurospora crassa chromosome 1 encodes a protein with a Gua_nucleotide_exch_fac_Ric8 domain and an ARM-type fold. The product binds G-alpha protein subunits and is annotated with GDS activity. It is associated with GPCR signaling, signal transduction, energy homeostasis, and protein synthesis. The gene is linked to asexual sporulation, sporulation, hyphal growth, and secondary metabolism. The protein localises to the membrane, cytoplasm, and cytosol. Studies of related genes in other species, including Fusarium and Verticillium species, link the family to similar signaling and developmental processes, though these associations are not yet established for N. crassa.