CLM2 — Neurospora crassa

Summary

NCU02852 (CLM2, NcCLM2) in Neurospora crassa chromosome 1 encodes a cytochrome P450 monooxygenase (CYP450-31) with heme and iron binding, and oxidoreductase activity acting on paired donors with incorporation of molecular oxygen. It is associated with ergosterol, sterol, ceramide, phospholipid, terpenoid, patulin, and antibiotic anabolism, as well as sterol homeostasis and hypersensitivity. The gene product localizes to the ER membrane. Phenotypic associations include decreased micronucleophagy, nucleophagy, and ribophagy; abnormal plasma membrane morphology, cell cycle progression, and entry into stationary phase; increased cell death; arrested vegetative and exponential growth; and altered nutrient, carbon, iron, and phosphorus utilization. Studies of related genes in other species link the family to ergosterol biosynthesis (ERG11, ERG24, ERG25, ERG26, ERG27, ERG28, ERG1, ERG3, ERG4, ERG7, ERG9) and protein content.