HIS2 — Neurospora crassa

Summary

NCU03139, also known as HIS2, his-3, or HIS7 in Neurospora crassa on chromosome 1, encodes a trifunctional histidine biosynthesis enzyme with phosphoribosyl-ATP diphosphatase (EC 3.5.4.19), phosphoribosyl-AMP cyclohydrolase (EC 3.6.1.31), and histidinol dehydrogenase (EC 1.1.1.23) activities, and binds NAD, ATP, and metal ions. The gene is associated with histidine anabolism, neutral amino acid transport, and a wide range of cellular processes including meiosis, mating, karyogamy, chromatin silencing, DNA repair, homologous recombination, and methylation. It is linked to abnormal mitochondrial transport, cell cycle arrest in S and G2 phases, decreased prion inheritance and pexophagy, altered pseudohyphal growth, reduced osmotic stress resistance and acquired thermotolerance, increased fermentative metabolism, and abnormal chromosome segregation, budding, and subcellular morphology. The protein localises to the cytoplasm and cytosol.