nca-1 — Neurospora crassa

Summary

NCU03305, symbol nca-1 on Neurospora crassa chromosome 1, encodes a P-type ATPase with potassium:proton transporter activity, K+-transporting ATPase activity, and additional cation transporter activities including sodium, manganese, and calcium transport. The gene is associated with cell-cell fusion, potassium and sodium ion export from the cell, cellular pH reduction, calcium ion import into the vacuole, manganese ion transport, and responses to unfolded proteins. It localizes to the plasma membrane at cell tips, medial membrane bands, endomembrane system, nuclear envelope, vacuolar membrane, Golgi membrane, and ER membrane. Studies of related genes in other species link the family to reduced virulence and pathogenicity, though these associations are not established for N. crassa itself.