KSG1 — Neurospora crassa

Summary

NCU03571 (KSG1, also known as PKH1, PKH2, stk-23) on Neurospora crassa chromosome 2 encodes a serine/threonine protein kinase with 3-phosphoinositide-dependent protein kinase activity, cAMP-dependent protein kinase activity, and PIP3 binding. It belongs to the AGC kinase family and the PDPK1 subfamily. The gene is associated with the sphingolipid-mediated signaling pathway, regulation of sphingolipid biosynthesis, glucose-sensing PKA pathway, adenylate cyclase-activating GPCR signaling, fungal-type cell wall organization, regulation of cytokinesis, and positive regulation of the cell integrity MAPK cascade. It is linked to microtubule destabilization, spindle assembly checkpoint, sister chromatid segregation, and meiotic spindle checkpoint. Phenotypic associations include increased necrotic cell death, altered endocytosis, increased UV and hydrostatic pressure resistance, increased starvation resistance, decreased chitin deposition, and abnormal plasma membrane morphology. The protein localizes to the spindle midzone, kinetochore, mitotic spindle pole body, cell cortex, and nucleoplasm.