DSCA — Neurospora crassa

Summary

NCU03740 (DSCA) on Neurospora crassa chromosome 5 encodes defective for SREBP cleavage protein A, a RING-type zinc-finger ubiquitin ligase (EC 2.3.2.27) with ubiquitin ligase activity and zinc binding. The protein localises to the Dsc E3 ubiquitin ligase complex, endomembrane system, Golgi membrane, and ER membrane. It is associated with ubiquitin-dependent protein catabolism via the MVB pathway, SREBP signalling, proteasomal pathway, hyphal growth, and hypersensitivity. Annotated associations link the gene to increased vegetative growth rate, increased lifespan, decreased spore germination, decreased osmotic stress resistance, increased mating response, abnormal autophagy, absent endocytosis, decreased iron utilisation, increased fermentative metabolism, and altered cell cycle progression including increased critical cell size at G1 and decreased G2 duration. Related genes in other species are linked to killer toxin resistance and oxidative stress response.