VPS75 — Neurospora crassa

Summary

NCU03769 (VPS75, naf-2) in Neurospora crassa encodes a NAP family protein with histone carrier activity, histone binding, and chromatin binding. It is associated with nucleosome assembly, CENP-A eviction from euchromatin, mitosis, and memory. The gene product localises to the nucleus, nucleoplasm, chromatin, centromere complex, and CENP-A-containing chromatin. Phenotypic associations include abnormal cell cycle progression through G1/S and metaphase-anaphase transitions, increased nuclear size, decreased meiotic recombination, increased silencing, decreased fermentative growth, decreased radiation resistance, and abnormal chitin deposition and cell size. Studies of related genes in other species link the family to chromatin regulation via interactions with RTT109, ASF1, and ESA1.