BIP1 — Neurospora crassa

Summary

NCU03982 (BIP1, also known as grp78) encodes a member of the Hsp70 family of molecular chaperones, specifically an endoplasmic reticulum (ER) luminal chaperone with ATP hydrolase activity and protein translocase activity. It is annotated with protein folding chaperone function, heat shock protein binding, and localization to the ER lumen, perinuclear ER, and cortical ER. The gene is associated with the unfolded protein response (UPR), the IRE1 branch of the UPR, ERAD pathway, protein refolding, secretion, sporulation, karyogamy during mating, and fungal-type cell wall beta-glucan biosynthesis. Phenotypic associations include abnormal nuclear fusion during mating, increased necrotic cell death, increased adhesion, delayed cell cycle progression, increased polyploidy and aneuploidy, decreased cell fusion, and abnormal autophagy. Related genes in other species link the family to ER stress responses and protein translocation.