GCN20 — Neurospora crassa

Summary

NCU04051 (GCN20) on Neurospora crassa chromosome 6 encodes an ABCF subfamily ATPase with ATP hydrolase activity, translation initiation factor binding, translation elongation factor activity, ribosome binding, GTPase activity, and RNA binding. The gene is associated with cytoplasmic translation initiation, elongation, and termination, ribosome biogenesis, poly(A)+ mRNA nuclear export, upregulation of translation initiation in response to starvation, upregulation of phosphorylation, and cellular response to histidine. The product localizes to the cytosol, nucleus, cytosolic ribosome, stress granules, plasma membrane, yeast-form cell wall, and fungal biofilm matrix. Phenotypic associations include increased osmotic and hyperosmotic stress resistance, decreased acquired thermotolerance, decreased freeze-thaw resistance, altered cell cycle progression, decreased pseudohyphal growth and biofilm formation, abnormal colony appearance and cell shape, decreased cell size, and altered respiratory and fermentative growth rates.