Bml — Neurospora crassa

Summary

NCU04054 (Bml, also known as NcTUB2, TUB2, NcNDA3, NDA3) on Neurospora crassa chromosome 6 encodes beta-tubulin, a structural constituent of the cytoskeleton with GTPase activity, GTP binding, and metal binding. The gene is associated with microtubule cytoskeleton organization, supramolecular fiber organization, mitotic spindle organization, mitotic chromosome segregation, the mitotic cell cycle, meiosis, and response to antibiotic. It localizes to microtubules and the cytoplasm. Phenotypic associations include abnormal colony size, cell cycle progression defects (delayed or increased duration in anaphase and metaphase, premature metaphase-anaphase transition, decreased S phase duration), abnormal or absent nuclear fusion during mating, arrested or premature meiosis, increased polyploidy and aneuploidy, decreased chromosome segregation, delayed growth, abnormal peroxisomal distribution, and absent apoptosis and late nucleophagy. Studies of related genes in other species link the family to resistance to chemicals, cold sensitivity, and altered virulence.