GST1 — Neurospora crassa

Summary

NCU04109 (GST1, also known as gst-2) encodes a glutathione S-transferase with glutathione transferase and peroxidase activities, and also possesses transcription corepressor and phosphoprotein binding activities. The protein localises to the cytoplasm, cytosol and nucleus. In Neurospora crassa, GST1 is associated with nitrate assimilation, regulation of nitrogen utilisation, protein urmylation, protein localisation, cellular detoxification, and negative regulation of RNA polymerase II transcription. The gene has been linked to numerous phenotypes including abnormal mating type switching, increased prion inheritance, decreased hypoosmotic stress resistance, increased nutrient and carbon source utilisation, abnormal fermentative and respiratory metabolism, decreased adhesion, abnormal nuclear transport, increased entry into G0 stationary phase, and sterility. Studies of related genes in other species connect the family to calcium sensitivity, phosphate content and oxidative stress response.