ERG5 — Neurospora crassa

Summary

NCU04234 (ERG5) on Neurospora crassa chromosome 5 encodes a cytochrome P450 monooxygenase with heme and iron binding, oxidoreductase activity acting on paired donors with oxygen incorporation. This gene is associated with ergosterol, terpenoid, hormone, antibiotic, and mycotoxin anabolism, as well as hypersensitivity. It localizes to the membrane. Phenotypic associations include increased fermentative growth, decreased endocytosis, absent micronucleophagy, abnormal telomere length and plasma membrane morphology, absent vacuolar transport, decreased meiosis, abnormal autophagy, decreased shmoo formation, increased budding, absent protein secretion, decreased colony size, increased small molecule transport, M-phase cell cycle arrest, G2/M transition delay, decreased cytokinesis, increased cell death, abnormal cytoskeleton and mitochondrial distribution, decreased nutrient uptake, abnormal peroxisomal morphology, decreased mating response, arrested vegetative growth, decreased apoptosis, and decreased mitochondrial genome maintenance. Studies of related genes in other species link the gene to potassium concentration and acid sensitivity traits.