RTI1 — Neurospora crassa

Summary

NCU04275 (RTI1, also known as RAD52) on Neurospora crassa chromosome 5 encodes a Rad52-family protein with recombinase activity, DNA reannealing activity, and DNA end-binding activity. It is associated with double-strand break repair via single-strand annealing, homologous recombination, meiotic joint molecule formation, replication fork arrest and processing, mitochondrial DNA repair, telomere maintenance via recombination, mating-type switching, and DNA damage tolerance. The protein localises to the nucleus, chromatin, mitochondria, and sites of double-strand breaks. Related genes in other species link the family to oxidative stress response.