CP1 — Neurospora crassa

Summary

NCU04316 (CP1) on Neurospora crassa chromosome 5 encodes a serine carboxypeptidase (EC 3.4.16.6) belonging to the peptidase S10 and alpha/beta hydrolase families. The gene is associated with diverse biological processes including proteolysis, chromatin silencing, nucleosome organization, mating, mitosis, apoptosis, DNA damage response, methylation, and memory. It is linked to the trans-Golgi network (TGN) localization. Phenotypic associations connect CP1 to altered cell death, autophagy, mitophagy, pexophagy, ribophagy, endocytosis, cytokinesis, nuclear fusion during mating, prion inheritance, aneuploidy, replicative lifespan, thermotolerance, and protein secretion. The gene is also associated with abnormal Golgi morphology, nuclear position, and entry into stationary phase. Studies of related genes in other species link the family to apoplastic effector functions and floral organ identity traits.