CHS5 — Neurospora crassa

Summary

NCU04352 (CHS5, chs-5) on Neurospora crassa chromosome 4 encodes a protein with chitin synthase activity (EC 2.4.1.16) and cytoskeletal motor activity, containing chitin synthase, myosin motor, and cytochrome b5-like domains. The gene is associated with chitin biosynthesis, GPI anchor anabolism, the MAPK cascade, asexual sporulation, ascospore formation, hyphal growth, fungal-type cell wall organization, morphogenesis, cell growth, and protein synthesis. Its product localizes to the plasma membrane, cell periphery, cell tip, cross wall, and myosin complex. Studies of related genes in other species link the family to reduced virulence and infection processes, though these associations are not established for N. crassa.