NIA — Neurospora crassa

Summary

NCU04474 (NIA) on Neurospora crassa chromosome 4 encodes a sulfite oxidase with nitrate reductase (NADPH) activity, cytochrome-b5 reductase activity acting on NAD(P)H, and FAD, heme, molybdenum cofactor and molybdenum ion binding, placing it in the mopterin oxidoreductase family. The gene is associated with nitrate assimilation, anaerobic respiration, nitric oxide anabolism, and sulfur metabolism, and its product localises to mitochondria. Related genes in other species link NIA to nitrate reductase (EC 1.7.1.3) activity. The gene has been connected to the NAR1 and NIA genes, and sequence similarity links it to proteins from Verticillium dahliae.