PMC1 — Neurospora crassa

Summary

NCU04736 (PMC1, also known as nca-2) on Neurospora crassa chromosome 6 encodes a P-type ATPase with potassium:proton transporter activity, K+-transporting ATPase activity, and calcium ion binding. This gene is associated with potassium ion export, sodium transport, calcium transport, proton export across the plasma membrane, and cellular ion homeostasis. It has been linked to vacuolar, Golgi, and ER membrane localization, as well as cell tip and medial membrane band distribution. Phenotypic associations include abnormal Golgi distribution, absent spore germination, decreased necrotic cell death, increased ionic stress resistance, and altered endocytosis, vacuolar transport, and cell cycle progression. Studies of related genes in other species link the family to calcium sensitivity and reduced virulence.