kin — Neurospora crassa

Summary

NCU05028 (kin) on Neurospora crassa chromosome 6 encodes a kinesin-like protein KIF22 with microtubule motor activity, including both plus-end- and minus-end-directed microtubule sliding, and ATP hydrolase activity. The gene is associated with meiotic spindle formation and assembly, mitotic spindle midzone assembly, metaphase spindle stability, microtubule anchoring at the mitotic spindle pole body, nuclear migration during mitotic telophase, mitotic anaphase spindle elongation, lateral attachment of spindle microtubules to kinetochores, plus-end-specific microtubule depolymerization, and microtubule bundling. It is also linked to protein transport along microtubules to kinetochores and establishment of microtubule cytoskeleton polarity. The product localises to microtubule minus- and plus-ends, polar and astral microtubules, and kinesin I and minus-end kinesin complexes. Related genes in other species link the family to microtubule dynamics and chromosome segregation.