TRP2 — Neurospora crassa

Summary

NCU05129 (TRP2, trp-2) on Neurospora crassa chromosome 6 encodes a protein with anthranilate synthase component I and ADC synthase domains, and is annotated with aminodeoxychorismate synthase activity, anthranilate synthase activity, and metal binding. This gene is associated with tryptophan formation, tetrahydrofolate anabolism, PABA biosynthesis, glutamine metabolism, and the blue light response. The encoded protein localises to the cytoplasm, cytosol, nucleus, and the anthranilate synthase complex. TRP2 is associated with numerous phenotypes including altered mating efficiency, abnormal plasma membrane and nuclear morphology, increased cell death and apoptosis, decreased spore germination and nutrient uptake, arrested vegetative growth and cell cycle progression, and decreased resistance to alkaline pH and hydrostatic pressure. Studies of related genes in other species link the family to oxidative stress response and acid sensitivity.