HTA3 — Neurospora crassa

Summary

NCU05347 (HTA3, hH2Az) on Neurospora crassa chromosome 2 encodes a histone H2A family protein with a Histone_H2A_C domain, and is associated with chromatin DNA binding, structural constituent of chromatin, protein heterodimerization activity, identical protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, and DNA binding. The gene is associated with nucleosome localization in euchromatin and the nucleus, and is linked to CENP-A eviction from euchromatin, non-stop decay, silent mating-type cassette chromatin silencing, chromatin silencing, RNA elongation from Pol II promoter, methylation, chromatin modeling, and regulation of transcription by RNA polymerase II. Phenotypically, HTA3 is associated with abnormal chemical compound excretion, absent entry into G0, altered cell cycle progression rates across G1, S, and G2 phases, increased sporulation rate, absent sporulation efficiency, abnormal mitophagy, absent apoptosis, and abnormal transposable element transposition. Related genes in other species link the family to calcium sensitivity, potassium concentration, acid sensitivity, and oxidative stress response.