TOR — Neurospora crassa

Summary

NCU05608, designated TOR (NcTOR) in Neurospora crassa on chromosome 6, encodes a serine/threonine-protein kinase with histone H2A kinase activity, pre-rRNA and protein complex binding, and ATP binding. It contains FRB, mTOR, TOR catalytic, PI3/4-kinase, FAT, FATC, and HEAT domains. TOR is associated with TORC1, the TOR complex, ATR-ATRIP complex, and Tor2-Mei2-Ste11 complex, localizing to nucleolar chromatin, perinuclear cytoplasm, and telomeric chromosome regions. It is linked to positive regulation of DNA replication, cytoplasmic translation, and ribosomal protein gene transcription, as well as negative regulation of rDNA heterochromatin, and suppression of macroautophagy. Phenotypic associations include altered carbon and nitrogen utilization, absent sporulation and alkaline pH resistance, increased virulence, abnormal cell cycle progression, and premature G1/S transition. Related genes in other species connect the family to oxidative stress response and protein content.