DBP2 — Neurospora crassa

Summary

NcDBP2 (NCU05782) on Neurospora crassa chromosome 7 encodes a DEAD-box RNA helicase (EC 3.6.4.13) with RNA helicase, mRNA binding, RNA binding, ATP hydrolase and ATP binding activities. The gene is associated with ribosome biogenesis, rRNA processing, endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA, RNA splicing, mRNA processing, and fruiting body formation. The product localises to the nucleolus and the preribosome large subunit precursor. Phenotypic associations include abnormal mitotic recombination, decreased mating type switching, absent sporulation efficiency, altered chemical resistance, increased thermotolerance, increased gamma ray resistance, delayed vegetative and exponential growth, increased fermentative growth, increased carbon source utilisation, and altered cell cycle progression including delayed G2/M phase transition, increased S phase rate, and premature G1/S transition. Studies of related genes in other species link the family to oxidative stress response.