CP1 — Neurospora crassa

Summary

NCU05980 (CP1) on Neurospora crassa chromosome 6 encodes a serine carboxypeptidase, belonging to the peptidase S10 and alpha/beta hydrolase families, with serine carboxypeptidase activity (EC 3.4.16.-). The gene is associated with proteolysis, chromatin silencing, nucleosome organization, mitosis, mating, DNA damage response, methylation, and memory. It is linked to the fungal-type vacuole, extracellular region, and plasma membrane. Phenotypic associations include increased acquired thermotolerance, altered prion inheritance, abnormal nuclear fusion during mating, increased aneuploidy, decreased ribophagy and mitophagy, abnormal autophagy and protein secretion, and increased lifespan. Studies of related genes in other species link the family to carboxypeptidase Y-like activity and apoplastic effector functions, though these are not established for N. crassa.