AIF1 — Neurospora crassa

Summary

NCU06061 (AIF1, NcAIF1) on Neurospora crassa chromosome 7 encodes an oxidoreductase with electron-transferring-flavoprotein dehydrogenase activity and FAD or FADH2 binding. The protein localises to the mitochondrial membrane, including the outer membrane, as well as the cytoplasm and nucleus. AIF1 is associated with negative regulation of ferroptosis, apoptotic mitochondrial changes, upregulation of apoptosis, cell death, and autophagy. It has also been linked to mating type switching, meiosis, and mating. Related genes in other species are linked to FAD/NAD(P)-binding domain-containing proteins and oxidoreductase activity (EC 1.6.5.-, 1.6.99.-).