mpp — Neurospora crassa

Summary

NCU06270 (symbol mpp, also known as MAS2 or NcMAS2) on Neurospora crassa chromosome 3 encodes a protein with domains of the MPP/UQCRC complex family, including Pept_M16_Zn_BS, Pept_M16_N, Peptidase_M16_C, and Metalloenz_LuxS/M16, and is annotated with metalloendopeptidase, signal peptidase, and endopeptidase activator activities. The gene is associated with mitochondrial protein processing and import, mitochondrial biogenesis, electron transfer, and protein processing. It localises to the mitochondrial processing peptidase complex, mitochondrial lumen, inner membrane and mitochondria. Phenotypically, mpp is associated with increased mutation frequency, abnormal chromosome/plasmid maintenance, increased chemical compound excretion, inviability, decreased oxidative stress resistance, increased heat sensitivity, decreased competitive fitness, and altered chemical resistance. Studies of related genes in other species connect the family to increased invasive growth and decreased starvation resistance.