trk — Neurospora crassa

Summary

NCU06449 (symbol trk) on Neurospora crassa chromosome 3 encodes a member of the Trk/HKT potassium transporter family, with chloride transmembrane transporter activity, high-affinity potassium ion transmembrane transporter activity, and chloride channel activity. The gene is associated with potassium ion import across the plasma membrane, cellular potassium ion homeostasis, regulation of membrane potential, cellular response to cation stress, chloride transport, response to toxic substances, and cell growth. It localises to the plasma membrane, cell tip, cell division site, medial membrane band, Golgi complex, and chloride channel complex. Phenotypic associations include abnormal cell cycle progression, absent meiosis and spore germination, increased anaerobic growth, altered endocytosis rates, and loss of desiccation and hyperosmotic stress resistance. Studies of related genes in other species link the family to potassium and sodium uptake, salt tolerance, and acid sensitivity.