GLX3 — Neurospora crassa

Summary

NCU06603, designated GLX3 in Neurospora crassa and located on chromosome 4, encodes a DJ-1/PfpI family protein with deglycase activity (EC 4.2.1.130). The gene is associated with cell differentiation and the biological process GO:0019243. Its product localises to the cytoplasm, cytosol, nucleus, yeast-form and hyphal cell walls, and the fungal biofilm matrix. GLX3 is associated with numerous phenotypes, including altered colony shape, decreased prion inheritance, increased autophagy, delayed G1/S cell cycle progression, increased telomere length, decreased gamma ray resistance, increased hyperosmotic stress resistance, decreased acquired thermotolerance, abnormal sporulation, and altered fermentative and respiratory growth rates. Related genes in other species are linked to oxidative stress response and loss of pathogenicity.