inl — Neurospora crassa

Summary

NCU06666 (symbol inl, also known as INO1) on Neurospora crassa chromosome 5 encodes a myo-inositol-1-phosphate synthase (EC 5.5.1.4) with inositol-3-phosphate synthase activity. This gene is associated with inositol and phospholipid anabolism, signal transduction, excretion, and mating. The encoded product localises to the cytoplasm, hyphal cell wall, and cell-bound compartments. NCU06666 is associated with decreased germination rate, absent meiosis, increased X-ray resistance, increased survival in stationary phase, decreased chitin deposition, increased aneuploidy, abnormal endocytosis, and altered pexophagy and nucleophagy. It is also linked to increased fermentative metabolism, decreased utilisation of iron and phosphorus sources, and altered cell cycle progression including S-phase arrest and G2/M delay. Related genes in other species are associated with oxidative stress response.