ACS1 — Neurospora crassa

Summary

NCU06836, also known as ACS1 or acu-5, encodes an acetyl-coenzyme A synthetase (EC 6.2.1.1) with amide synthase activity, AMP binding and ATP binding, placing it in the ANL superfamily of adenylate-forming enzymes. In Neurospora crassa, this gene is associated with acetate and acetoin breakdown, acetyl-CoA anabolism, the glyoxylate cycle, TCA cycle, pyruvate fermentation to acetate, carbon catabolite repression, and penicillin anabolism. It is linked to nucleolar, cytosolic and extracellular localisation. Phenotypic associations include abnormal carbon source utilisation, decreased fermentative growth and metabolism, absent pheromone production and sensitivity, sterile phenotype, decreased hypoosmotic stress resistance, increased X-ray resistance, abnormal vacuolar and Golgi morphology, delayed cell cycle metaphase-anaphase transition, increased critical cell size at the G1 checkpoint, and absent adhesion and late nucleophagy. Related genes in other species link the acetyl-CoA synthetase family to protein content.