SWI10 — Neurospora crassa

Summary

NCU07066, also known as SWI10 or mus-44 in Neurospora crassa on chromosome 6, encodes a protein of the ERCC1/RAD10/SWI10 family with endonuclease activity, as well as hydrolase activity, damaged DNA binding, single-stranded DNA binding, and polyubiquitin modification-dependent protein binding. This gene is associated with multiple DNA repair pathways, including nucleotide excision repair (NER), interstrand crosslink (ICL) repair, double-strand break repair via single-strand annealing, and ultraviolet damage excision repair (UVER). It is also linked to mating-type switching, gene conversion at the mating-type locus, and mitotic recombination. The protein localizes to the XPF-ERCC1 and NEF1 complexes, the nucleus, cytoplasm, and sites of double-strand breaks. Phenotypically, SWI10 is associated with decreased sporulation, vegetative growth rate, competitive fitness, and heat sensitivity, as well as increased chronological lifespan and altered responses to chemicals and metals.