CLM2 — Neurospora crassa

Summary

NCU07092, symbol CLM2 in Neurospora crassa on chromosome 6, encodes a cytochrome P450 monooxygenase with heme and iron binding, oxidoreductase and monooxygenase activities. The gene is associated with ergosterol, sterol, ceramide, phospholipid and antibiotic biosynthesis, sterol homeostasis, and small molecule biosynthesis. CLM2 is linked to numerous phenotypes including decreased micronucleophagy, nucleophagy and ribophagy; absent hyperosmotic stress resistance and cytokinesis; abnormal plasma membrane morphology, cell cycle progression, and entry into stationary phase; increased cell death and fermentative metabolism; arrested vegetative and exponential growth; and decreased invasive growth, nutrient uptake, and utilization of iron and phosphorus sources. The gene product localises to membranes. Studies of related genes in other species link the family to ergosterol biosynthesis.