HOG1 — Neurospora crassa

Summary

NCU07024 (HOG1, os-2) on Neurospora crassa chromosome 4 encodes a mitogen-activated protein kinase (MAPK) of the p38/Hog1 family, with protein serine/threonine kinase activity (EC 2.7.11.24) and ATP binding. The gene is associated with the stress-activated MAPK cascade, osmolarity sensing, and the HOG response, as well as circadian rhythm, conidiophore development, germ tube formation, and nuclear division. It is linked to glycerol and glycogen anabolism, ceramide anabolism, gluconeogenesis, and response to heat. The encoded protein localizes to both the cytoplasm and nucleus. Associations include phosphorus uptake, oxidative stress response, and numerous phenotypes such as absent osmotic stress resistance, decreased cell cycle progression rate, absent mating efficiency, increased acquired thermotolerance, and abnormal flocculation. Studies of related genes in other species link the family to turgor pressure, germination rate, and virulence.