hH1 — Neurospora crassa

Summary

NCU06863, also known as hH1, NcPKAC2, and NPKA, encodes a protein with a Histone_H1/H5_H15 domain on Neurospora crassa chromosome 7. The product is a structural constituent of chromatin that binds DNA, including supercoiled, double-stranded, and nucleosomal DNA, and also binds phosphate ions. It is localized to the nucleus, condensed nuclear chromosomes, nucleosomes, and the fungal biofilm matrix. This gene is associated with chromosome condensation, nucleosome assembly, regulation of DNA-templated transcription, mitosis, cell division, cell cycle, DNA repair, methylation, sporulation, bioluminescence, and digestion, as well as downregulation of DNA recombination. Studies of related genes in other species link the family to unaffected pathogenicity, though this has not been established for N. crassa.