DHC1 — Neurospora crassa

Summary

NCU06976, also known as DHC1, ro-1, or NcDYN1, encodes a dynein heavy chain, a core component of the cytoplasmic dynein complex that possesses minus-end-directed microtubule motor activity, ATP hydrolase activity, and binds tubulin, dynein intermediate chains, and dynein light intermediate chains. In Neurospora crassa, DHC1 is associated with nuclear migration along microtubules, organelle and vesicle transport, homologous chromosome pairing at meiosis, karyogamy, metula development, and mitotic spindle organization and orientation. The gene is linked to cell cycle progression, particularly delayed or arrested anaphase, delayed telophase, and premature G2/M transition, as well as abnormal chromosome segregation, increased nuclear size, and abnormal mitochondrial transport. DHC1 localizes to the dynein complex, cytoplasmic microtubules, astral microtubules, the meiotic spindle pole body, and the hyphal tip.