GSY1 — Neurospora crassa

Summary

NCU06687 (GSY1) on Neurospora crassa chromosome 5 encodes a glycogen synthase (EC 2.4.1.11) with glycogen (starch) synthase activity, localizing to the cytoplasm and glycogen granules. It is associated with glycogen anabolism and bioluminescence. The gene has been linked to numerous phenotypes including altered cell cycle progression (metaphase and anaphase duration, M phase rate, passage through START and the metaphase-anaphase transition), abnormal pheromone sensitivity and cell cycle arrest, decreased spore germination, absent or increased fermentative and anaerobic growth, altered desiccation and freeze-thaw resistance, changes in nucleus size, decreased entry into G0 stationary phase, reduced nitrogen source utilization, absent adhesion, and altered protein/peptide accumulation and modification. Studies of related genes in other species link the family to unaffected or reduced virulence.