TOM20 — Neurospora crassa

Summary

NCU06632, designated TOM20 in Neurospora crassa and located on chromosome 4, encodes a mitochondrial outer membrane translocase component belonging to the Tom20 domain superfamily (also known as MAS20 or mom19). The protein exhibits mitochondrion targeting sequence binding and ATP hydrolase activity. TOM20 is associated with mitochondrial protein import, including matrix protein import, as well as tRNA import into the mitochondrion and intracellular protein transport. It localises to the mitochondrial outer membrane translocase (TOM) complex. Phenotypic associations link TOM20 to altered mitochondrial transport, respiratory metabolism, prion inheritance, peroxisomal morphology and transport, cell death, mitophagy, chitin deposition, spore germination, colony shape, survival in stationary phase, acid pH resistance, fermentative metabolism, redox state, and nuclear import. Related genes in other species connect the family to mitochondrial functions.